Forget me not: Novel target shows promise in treating Alzheimer's and related dementias

(Medical University of South Carolina) Researchers at the Medical University of South Carolina and Harvard Medical School have identified a previously unknown early driver of Alzheimer's disease (AD) and vascular dementia (VaD). In Science Translational Medicine, they report high levels of cis P-tau, a pathogenic protein, in human AD and VaD brains as well as preclinical disease models. Treatment with an antibody to the toxic protein prevented disease progression and reversed disease symptoms an...